At first glance, Busselton Jetty might seem like a beloved tourist attraction and a historic landmark, but beneath the waves lies something far more extraordinary—an untapped resource with the potential to revolutionise cancer treatment.
In a pioneering research initiative, scientists from The University of Western Australia (UWA), led by marine chemist Dr. Darren Holland, are investigating the medicinal properties of marine sponges living under the Jetty. These ancient organisms have evolved in the oceans for millions of years, and their unique adaptations could hold the key to new anti-cancer therapies.
The Hidden Treasure Beneath the Jetty
Marine sponges are known for their incredible biodiversity, especially in Busselton Jetty’s waters, where more than 300 species thrive, forming Australia’s largest artificial reef. These sponges, often overlooked, produce natural compounds as a defence mechanism against their environment, making them a rich source for drug discovery.
Dr. Holland, who recently returned from a postdoctoral fellowship at the prestigious Scripps Institution of Oceanography, explains that many modern drugs, including those used to treat cancer, are derived from natural products. “Sponges have evolved alongside pathogenic microbes and viruses, making them exceptional at producing compounds with potential therapeutic value,” says Dr. Holland.
Some sponge-derived compounds, such as Phorboxazole A and Aurantoside C, found off Western Australia’s coast, have already shown significant anticancer properties. This new research aims to expand on these findings by exploring the medicinal potential of approximately 20 sponge species collected from Busselton Jetty.
From the Lab to the Community
The first phase of the project will focus on analysing these sponge species to create an extract library for in vitro (lab-based) anticancer screening. If successful, the research could identify promising new compounds for further drug development.
Beyond the lab, Busselton Jetty’s Marine Discovery Centre will play a key role in engaging the local community with this scientific endeavour. Visitors will have the opportunity to learn about the project and the importance of marine ecosystems in scientific research.
A Collaborative Effort with Long-Term Impact
This project is not just about uncovering potential cures—it’s about building a sustainable future. The team, which also includes Associate Professors Heng Chooi and Gavin Flematti from UWA, aims to integrate aquaculture and DNA sequencing into their research to ensure the sustainable production of these sponge-derived compounds. This approach will help preserve marine ecosystems while advancing cancer research.
“We’re excited to be part of a project that could have far-reaching implications,” says Busselton Jetty CEO Lisa Shreeve, who has been instrumental in bringing together this collaboration between UWA and Busselton Jetty. “It’s an inspiring example of how tourism, environmental stewardship, and scientific research can work together.”
Community Support Drives Research Forward
The excitement around this project was evident at the recent Busselton Jetty Environment Foundation (BJEF) Charity Golf Day, which raised funds to support the research. The event, held at Busselton Golf Club, saw 148 participants swinging for a cure, including UWA’s Dr. Darren Holland and former WA Chief Scientist Professor Lyn Beazley.
Professor Beazley shared insights into the project, explaining how compounds found in sponges, such as Phorbas, are already showing biological activity against cancer cells. “This research could open doors to innovative cancer treatments, and the community’s support plays a crucial role in making that happen,” she said.
Join Us on This Journey of Discovery
Busselton Jetty is proud to contribute to this groundbreaking research, which highlights our commitment to sustainability, science, and community engagement. We invite visitors and locals alike to join us in our Sea of Discovery, where the beauty of Geographe Bay meets the frontlines of cancer research.
For more information on this exciting project, make sure you follow our socials and keep an eye out for updated blog posts.
